Multiple chemical sensitivity ( MCS), also known as idiopathic environmental intolerances ( IEI), is a complex characterized by that the affected person attributes to encountering small amounts of common substances, such as. The etiology, diagnosis and treatment of MCS are controversial and still debated among researchers, but a 2018 review concluded that a hyperactive and autonomic nervous system were confirmed features of the condition. A 2018 concluded that the evidence suggests that organic abnormalities in sensory processing pathways and the limbic system combined with some specific, uncommon (such as heightened ) best explains this condition.

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Commonly attributed substances for MCS symptoms include scented products,, plastics, synthetic fabrics, smoke, products, and paint fumes. MCS symptoms are typically vague. They may include,,,. Although the symptoms of MCS themselves are real, and can be disabling, MCS is not recognized as a separate, discrete disease by the,, or by several other professional medical organizations. Some clinical trials have shown that the study subjects reacted as often and as strongly to as they did to chemical stimuli and that the presence of symptoms was related to the perception that a chemical stimulus was present.

Some experts attribute the symptoms to depression,,.